A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via e...
A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation—transcription coupling
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Publisher
Washington: National Academy of Sciences
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Language
English
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Publisher
Washington: National Academy of Sciences
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Contents
Elevation of intracellular Ca2+ concentration ([Ca2+]i) activates Ca2+/calmodulin-dependent kinases (CaMK) and promotes gene transcription. This signaling pathway is referred to as excitation—transcription (E-T) coupling. Although vascular myocytes can exhibit E-T coupling, the molecular mechanisms and physiological/pathological roles are unknown....
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Full title
A molecular complex of Cav1.2/CaMKK2/CaMK1a in caveolae is responsible for vascular remodeling via excitation—transcription coupling
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9169798
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9169798
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2117435119
