Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-2...
Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24
About this item
Full title
Author / Creator
Cong, Zhaotong , Zhou, Qingtong , Li, Yang , Chen, Li-Nan , Zhang, Zi-Chen , Liang, Anyi , Liu, Qing , Wu, Xiaoyan , Dai, Antao , Xia, Tian , Wu, Wei , Zhang, Yan , Yang, Dehua and Wang, Ming-Wei
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Glucagon-like peptide-1 receptor (GLP-1R) agonists are effective in treating type 2 diabetes and obesity with proven cardiovascular benefits. However, most of these agonists are peptides and require subcutaneous injection except for orally available semaglutide. Boc5 was identified as the first orthosteric nonpeptidic agonist of GLP-1R that mimics...
Alternative Titles
Full title
Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9171782
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9171782
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2200155119
