Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of...
Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autophagy and pH, multiplex confocal imaging and correlative light electron microscopy. Autolysosome acidification d...
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Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9174056
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9174056
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-022-01084-8
