Disruption of mitochondrial complex I induces progressive parkinsonism
Disruption of mitochondrial complex I induces progressive parkinsonism
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson’s disease
1
. Yet, whether this change contributes to Parkinson’s disease pathogenesis is unclear
2
. Here we used intersectional genetics to disrupt the function of MCI in mouse dopaminergic neurons. Disruptio...
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Full title
Disruption of mitochondrial complex I induces progressive parkinsonism
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9189968
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9189968
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-04059-0
