Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (h...
Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter
About this item
Full title
Author / Creator
Gu, Wei , Lin, Zihan , Zhao, Shengchao , Wang, Guanzhen , Shen, Ziyi , Liu, Wei , Cai, Yi , Wang, Kaibo , Wan, Chunpeng Craig and Yan, Tingdong
Publisher
United States: Hindawi
Journal title
Language
English
Formats
Publication information
Publisher
United States: Hindawi
Subjects
More information
Scope and Contents
Contents
The upregulation telomerase activity is observed in over 85-90% of human cancers and provides an attractive target for cancer therapies. The high guanine content in the telomere DNA sequences and the hTERT promoter can form G-quadruplexes (G4s). Small molecules targeting G4s in telomeres and hTERT promoter could stabilize the G4s and inhibit hTERT...
Alternative Titles
Full title
Research Progress on G-Quadruplexes in Human Telomeres and Human Telomerase Reverse Transcriptase (hTERT) Promoter
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9192192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9192192
Other Identifiers
ISSN
1942-0900
E-ISSN
1942-0994
DOI
10.1155/2022/2905663
