Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis
Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis
About this item
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Author / Creator
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
The crosstalk between the BM microenvironment (niche) and hematopoietic stem cells (HSCs) is critical for HSC regeneration. Here, we show that in mice, deletion of the Fanconi anemia (FA) genes Fanca and Fancc dampened HSC regeneration through direct effects on HSCs and indirect effects on BM niche cells. FA HSCs showed persistent upregulation of t...
Alternative Titles
Full title
Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9197516
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9197516
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI155914
