LIN28 coordinately promotes nucleolar/ ribosomal functions and represses the 2C-like transcriptional...
LIN28 coordinately promotes nucleolar/ ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells
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Author / Creator
Sun, Zhen , Yu, Hua , Zhao, Jing , Tan, Tianyu , Pan, Hongru , Zhu, Yuqing , Chen, Lang , Zhang, Cheng , Zhang, Li , Lei, Anhua , Xu, Yuyan , Bi, Xianju , Huang, Xin , Gao, Bo , Wang, Longfei , Correia, Cristina , Chen, Ming , Sun, Qiming , Feng, Yu , Shen, Li , Wu, Hao , Wang, Jianlong , Shen, Xiaohua , Q. Daley, George , Li, Hu and Zhang, Jin
Publisher
Beijing: Higher Education Press
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Language
English
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Beijing: Higher Education Press
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Contents
LIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs, and few have addressed LIN28's role within the nucleus. Here, we show tha...
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Full title
LIN28 coordinately promotes nucleolar/ ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9226220
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9226220
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ISSN
1674-800X,1674-8018
E-ISSN
1674-8018
DOI
10.1007/s13238-021-00864-5
