Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy...
Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy: cellular mechanisms and implications for diastolic function
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Author / Creator
Coppini, Raffaele , Beltrami, Matteo , Doste, Ruben , Bueno-Orovio, Alfonso , Ferrantini, Cecilia , Vitale, Giulia , Pioner, Josè Manuel , Santini, Lorenzo , Argirò, Alessia , Berteotti, Martina , Mori, Fabio , Marchionni, Niccolò , Stefàno, Pierluigi , Cerbai, Elisabetta , Poggesi, Corrado and Olivotto, Iacopo
Publisher
Oxford: Oxford University Press
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Language
English
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Publisher
Oxford: Oxford University Press
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Abstract
Aims
Ventricular cardiomyocytes from hypertrophic cardiomyopathy (HCM) patient hearts show prolonged action potential duration (APD), impaired intracellular Ca2+ homeostasis and abnormal electrical response to beta -adrenergic stimulation. We sought to determine whether this behaviour is associated with abnormal changes of repolariza...
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Full title
Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy: cellular mechanisms and implications for diastolic function
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9242073
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9242073
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ISSN
2752-4191
E-ISSN
2752-4191
DOI
10.1093/ehjopen/oeac034