Lepr+ mesenchymal cells sense diet to modulate intestinal stem/progenitor cells via Leptin–Igf1 axis
Lepr+ mesenchymal cells sense diet to modulate intestinal stem/progenitor cells via Leptin–Igf1 axis
About this item
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Author / Creator
Deng, Min , Guerrero-Juarez, Christian F. , Sheng, Xiaole , Xu, Jiuzhi , Wu, Xi , Yao, Kai , Li, Mengzhen , Yang, Xu , Li, Guilin , Xiao, Jintao , Liu, Xiaowei , Wu, Kaichun , Ren, Fazheng , Nie, Qing , Plikus, Maksim V. , Yu, Zhengquan and Lv, Cong
Publisher
Singapore: Springer Nature Singapore
Journal title
Language
English
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Publication information
Publisher
Singapore: Springer Nature Singapore
Subjects
More information
Scope and Contents
Contents
Diet can impact on gut health and disease by modulating intestinal stem cells (ISCs). However, it is largely unknown if and how the ISC niche responds to diet and influences ISC function. Here, we demonstrate that Lepr
+
mesenchymal cells (MCs) surrounding intestinal crypts sense diet change and provide a novel niche signal to maintain ISC an...
Alternative Titles
Full title
Lepr+ mesenchymal cells sense diet to modulate intestinal stem/progenitor cells via Leptin–Igf1 axis
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9253134
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9253134
Other Identifiers
ISSN
1748-7838,1001-0602
E-ISSN
1748-7838
DOI
10.1038/s41422-022-00643-9
