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Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nano...

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nano...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9273165

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

About this item

Full title

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

Publisher

Abingdon: Taylor & Francis

Journal title

Green chemistry letters and reviews, 2021-10, Vol.14 (4), p.578-599

Language

English

Formats

Publication information

Publisher

Abingdon: Taylor & Francis

More information

Scope and Contents

Contents

A metal-free, atom-economy and simple work-up domino amination-Knoevenagel condensation approach to construct new coumarin analogous (4a-f and 8a-e) was described. Further, new formyl (5a,d-f) and nitro (9a,d-f) coumarin derivatives were synthesized via C-N coupling reaction of various cyclic secondary amines and 4-chloro-3-(formyl-/nitro)coumarins...

Alternative Titles

Full title

Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9273165

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9273165

Other Identifiers

ISSN

1751-8253

E-ISSN

1751-7192

DOI

10.1080/17518253.2021.1981462

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