Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia mo...
Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model
About this item
Full title
Author / Creator
Arkoun, Brahim , Robert, Elie , Boudia, Fabien , Mazzi, Stefania , Dufour, Virginie , Siret, Aurélie , Mammasse, Yasmine , Aid, Zakia , Vieira, Matthieu , Aygun, Imanci , Aglave, Marine , Cambot, Marie , Petermann, Rachel , Souquere, Sylvie , Rameau, Philippe , Catelain, Cyril , Diot, Romain , Tachdjian, Gérard , Hermine, Olivier , Droin, Nathalie , Debili, Najet , Plo, Isabelle , Malinge, Sébastien , Soler, Eric , Raslova, Hana , Mercher, Thomas and Vainchenker, William
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional driver mutations. We modeled the megakaryocyte differentiation defect through stepwise gene editing of GATA1s, S...
Alternative Titles
Full title
Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model
Authors, Artists and Contributors
Author / Creator
Robert, Elie
Boudia, Fabien
Mazzi, Stefania
Dufour, Virginie
Siret, Aurélie
Mammasse, Yasmine
Aid, Zakia
Vieira, Matthieu
Aygun, Imanci
Aglave, Marine
Cambot, Marie
Petermann, Rachel
Souquere, Sylvie
Rameau, Philippe
Catelain, Cyril
Diot, Romain
Tachdjian, Gérard
Hermine, Olivier
Droin, Nathalie
Debili, Najet
Plo, Isabelle
Malinge, Sébastien
Soler, Eric
Raslova, Hana
Mercher, Thomas
Vainchenker, William
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9282925
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9282925
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI156290
