Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
About this item
Full title
Author / Creator
Chen, Lei-Lei , Morcelle, Carmen , Cheng, Zhou-Li , Chen, Xiufei , Xu, Yanping , Gao, Yajing , Song, Junbin , Li, Zhijun , Smith, Matthew D. , Shi, Miao , Zhu, Yezhang , Zhou, Neng , Cheng, Meng , He, Chenxi , Liu, Kwei‐Yan , Lu, Guoping , Zhang, Lei , Zhang, Cheng , Zhang, Jinye , Sun, Yiping , Qi, Tuan , Lyu, Yingying , Ren, Zhi-Zhong , Tan, Xian-Ming , Yin, Jiayong , Lan, Fei , Liu, Ying , Yang, Hui , Qian, Maoxiang , Duan, Caiwen , Chang, Xing , Zhou, Yufeng , Shen, Li , Baldwin, Albert S. , Guan, Kun-Liang , Xiong, Yue and Ye, Dan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
As one of the most induced genes in activated macrophages,
immune-responsive gene 1
(
IRG1
) encodes a mitochondrial metabolic enzyme catalysing the production of itaconic acid (ITA). Although ITA has an anti-inflammatory property, the underlying mechanisms are not fully understood. Here we show that ITA is a potent inhibitor of the TET...
Alternative Titles
Full title
Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
Authors, Artists and Contributors
Author / Creator
Morcelle, Carmen
Cheng, Zhou-Li
Chen, Xiufei
Xu, Yanping
Gao, Yajing
Song, Junbin
Li, Zhijun
Smith, Matthew D.
Shi, Miao
Zhu, Yezhang
Zhou, Neng
Cheng, Meng
He, Chenxi
Liu, Kwei‐Yan
Lu, Guoping
Zhang, Lei
Zhang, Cheng
Zhang, Jinye
Sun, Yiping
Qi, Tuan
Lyu, Yingying
Ren, Zhi-Zhong
Tan, Xian-Ming
Yin, Jiayong
Lan, Fei
Liu, Ying
Yang, Hui
Qian, Maoxiang
Duan, Caiwen
Chang, Xing
Zhou, Yufeng
Shen, Li
Baldwin, Albert S.
Guan, Kun-Liang
Xiong, Yue
Ye, Dan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9305987
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9305987
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/s41556-022-00853-8
