Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis
Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis
About this item
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Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
Drugs are often withdrawn from the market due to the manifestation of drug-induced liver injury (DILI) in patients. Drug-induced cholestasis (DIC), defined as obstruction of hepatic bile flow due to medication, is one form of DILI. Because DILI is idiosyncratic, and the resulting cholestasis complex, there is no suitable in vitro model for early DI...
Alternative Titles
Full title
Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9325861
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9325861
Other Identifiers
ISSN
0340-5761
E-ISSN
1432-0738
DOI
10.1007/s00204-022-03321-2
