ADAR1 averts fatal type I interferon induction by ZBP1
ADAR1 averts fatal type I interferon induction by ZBP1
About this item
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Author / Creator
Jiao, Huipeng , Wachsmuth, Laurens , Wolf, Simone , Lohmann, Juliane , Nagata, Masahiro , Kaya, Göksu Gökberk , Oikonomou, Nikos , Kondylis, Vangelis , Rogg, Manuel , Diebold, Martin , Tröder, Simon E. , Zevnik, Branko , Prinz, Marco , Schell, Christoph , Young, George R. , Kassiotis, George and Pasparakis, Manolis
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
Mutations of the
ADAR1
gene encoding an RNA deaminase cause severe diseases associated with chronic activation of type I interferon (IFN) responses, including Aicardi–Goutières syndrome and bilateral striatal necrosis
1
–
3
. The IFN-inducible p150 isoform of ADAR1 contains a Zα domain that recognizes RNA with an alternative left-...
Alternative Titles
Full title
ADAR1 averts fatal type I interferon induction by ZBP1
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9329096
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9329096
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04878-9
