Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic im...
Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Gain-of-function kinase mutations are common in AML and usually portend an inferior prognosis. We reported a novel mechanism whereby kinase mutants induced intracellular alkalization characteristic in oncogenesis. Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hematopoietic progenitors, of which FLT3-ITD, KRAS
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Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9343251
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9343251
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-022-01606-0
