Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury pa...
Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway
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Author / Creator
Wen, Li , Tao, Shao-hua , Guo, Fan , Li, Ling-zhi , Yang, Hong-liu , Liang, Yan , Zhang, Li-dan , Ma, Liang and Fu, Ping
Publisher
Singapore: Springer Nature Singapore
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Language
English
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Publisher
Singapore: Springer Nature Singapore
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Contents
Enhancer of zeste homolog 2 (EZH2), a component of polycomb repressive complex 2 (PRC2), is a histone lysine methyltransferase mediating trimethylation of histone H3 at lysine 27 (H3K27me3), which is a repressive marker at the transcriptional level. EZH2 sustains normal renal function and its overexpression has bad properties. Inhibition of EZH2 ov...
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Full title
Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9343430
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9343430
Other Identifiers
ISSN
1671-4083
E-ISSN
1745-7254
DOI
10.1038/s41401-021-00837-8
