Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral...
Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells
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Author / Creator
Csomos, Krisztian , Ujhazi, Boglarka , Blazso, Peter , Herrera, Jose L. , Tipton, Christopher M. , Kawai, Tomoki , Gordon, Sumai , Ellison, Maryssa , Wu, Kevin , Stowell, Matthew , Haynes, Lauren , Cruz, Rachel , Zakota, Bence , Nguyen, Johnny , Altrich, Michelle , Geier, Christoph B. , Sharapova, Svetlana , Dasso, Joseph F. , Leiding, Jennifer W. , Smith, Grace , Al-Herz, Waleed , de Barros Dorna, Mayra , Fadugba, Olajumoke , Fronkova, Eva , Kanderova, Veronika , Svaton, Michael , Henrickson, Sarah E. , Hernandez, Joseph D. , Kuijpers, Taco , Kandilarova, Snezhina Mihailova , Naumova, Elizaveta , Milota, Tomas , Sediva, Anna , Moshous, Despina , Neven, Benedicte , Saco, Tara , Sargur, Ravishankar , Savic, Sinisa , Sleasman, John , Sunkersett, Gauri , Ward, Brant R. , Komatsu, Masanobu , Pittaluga, Stefania , Kumanovics, Attila , Butte, Manish J. , Cancro, Michael P. , Pillai, Shiv , Meffre, Eric , Notarangelo, Luigi D. and Walter, Jolan E.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The recombination-activating genes (
RAG
) 1 and 2 are indispensable for diversifying the primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the bone marrow; however, the impact of
RAG1
/
RAG2
on peripheral tolerance is unknown. Partial RAG deficiency (pRD) manifesting with late-onset immun...
Alternative Titles
Full title
Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells
Authors, Artists and Contributors
Author / Creator
Ujhazi, Boglarka
Blazso, Peter
Herrera, Jose L.
Tipton, Christopher M.
Kawai, Tomoki
Gordon, Sumai
Ellison, Maryssa
Wu, Kevin
Stowell, Matthew
Haynes, Lauren
Cruz, Rachel
Zakota, Bence
Nguyen, Johnny
Altrich, Michelle
Geier, Christoph B.
Sharapova, Svetlana
Dasso, Joseph F.
Leiding, Jennifer W.
Smith, Grace
Al-Herz, Waleed
de Barros Dorna, Mayra
Fadugba, Olajumoke
Fronkova, Eva
Kanderova, Veronika
Svaton, Michael
Henrickson, Sarah E.
Hernandez, Joseph D.
Kuijpers, Taco
Kandilarova, Snezhina Mihailova
Naumova, Elizaveta
Milota, Tomas
Sediva, Anna
Moshous, Despina
Neven, Benedicte
Saco, Tara
Sargur, Ravishankar
Savic, Sinisa
Sleasman, John
Sunkersett, Gauri
Ward, Brant R.
Komatsu, Masanobu
Pittaluga, Stefania
Kumanovics, Attila
Butte, Manish J.
Cancro, Michael P.
Pillai, Shiv
Meffre, Eric
Notarangelo, Luigi D.
Walter, Jolan E.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9355881
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9355881
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-022-01271-6
