Recording gene expression order in DNA by CRISPR addition of retron barcodes
Recording gene expression order in DNA by CRISPR addition of retron barcodes
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Biological processes depend on the differential expression of genes over time, but methods to make physical recordings of these processes are limited. Here we report a molecular system for making time-ordered recordings of transcriptional events into living genomes. We do this through engineered RNA barcodes, based on prokaryotic retrons
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Full title
Recording gene expression order in DNA by CRISPR addition of retron barcodes
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9357182
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9357182
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04994-6
