Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mecha...
Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
About this item
Full title
Author / Creator
Barc, Julien , Tadros, Rafik , Glinge, Charlotte , Chiang, David Y. , Jouni, Mariam , Simonet, Floriane , Jurgens, Sean J. , Baudic, Manon , Nicastro, Michele , Potet, Franck , Offerhaus, Joost A. , Walsh, Roddy , Choi, Seung Hoan , Verkerk, Arie O. , Mizusawa, Yuka , Anys, Soraya , Minois, Damien , Arnaud, Marine , Duchateau, Josselin , Wijeyeratne, Yanushi D. , Muir, Alison , Papadakis, Michael , Castelletti, Silvia , Torchio, Margherita , Ortuño, Cristina Gil , Lacunza, Javier , Giachino, Daniela F. , Cerrato, Natascia , Martins, Raphaël P. , Campuzano, Oscar , Van Dooren, Sonia , Thollet, Aurélie , Kyndt, Florence , Mazzanti, Andrea , Clémenty, Nicolas , Bisson, Arnaud , Corveleyn, Anniek , Stallmeyer, Birgit , Dittmann, Sven , Saenen, Johan , Noël, Antoine , Honarbakhsh, Shohreh , Rudic, Boris , Marzak, Halim , Rowe, Matthew K. , Federspiel, Claire , Le Page, Sophie , Placide, Leslie , Milhem, Antoine , Barajas-Martinez, Hector , Beckmann, Britt-Maria , Krapels, Ingrid P. , Steinfurt, Johannes , Winkel, Bo Gregers , Jabbari, Reza , Shoemaker, Moore B. , Boukens, Bas J. , Škorić-Milosavljević, Doris , Bikker, Hennie , Manevy, Federico C. , Lichtner, Peter , Ribasés, Marta , Meitinger, Thomas , Müller-Nurasyid, Martina , Veldink, Jan H. , van den Berg, Leonard H. , Van Damme, Philip , Cusi, Daniele , Lanzani, Chiara , Rigade, Sidwell , Charpentier, Eric , Baron, Estelle , Bonnaud, Stéphanie , Lecointe, Simon , Donnart, Audrey , Le Marec, Hervé , Chatel, Stéphanie , Karakachoff, Matilde , Bézieau, Stéphane , London, Barry , Tfelt-Hansen, Jacob , Roden, Dan , Odening, Katja E. , Cerrone, Marina , Chinitz, Larry A. , Volders, Paul G. , van de Berg, Maarten P. , Laurent, Gabriel , Faivre, Laurence , Antzelevitch, Charles , Kääb, Stefan , Al Arnaout, Alain , Dupuis, Jean-Marc , Pasquie, Jean-Luc , Billon, Olivier , Roberts, Jason D. , Jesel, Laurence , Borggrefe, Martin and Lambiase, Pier D.
Journal title
Language
English
Formats
More information
Scope and Contents
Contents
Brugada syndrome is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of
SCN5A
, encoding the cardiac sodium channel Na
v
1.5, susceptibility genes remain largely unknown. Here we performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with Brugada syndrome and 10,0...
Alternative Titles
Full title
Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Authors, Artists and Contributors
Author / Creator
Tadros, Rafik
Glinge, Charlotte
Chiang, David Y.
Jouni, Mariam
Simonet, Floriane
Jurgens, Sean J.
Baudic, Manon
Nicastro, Michele
Potet, Franck
Offerhaus, Joost A.
Walsh, Roddy
Choi, Seung Hoan
Verkerk, Arie O.
Mizusawa, Yuka
Anys, Soraya
Minois, Damien
Arnaud, Marine
Duchateau, Josselin
Wijeyeratne, Yanushi D.
Muir, Alison
Papadakis, Michael
Castelletti, Silvia
Torchio, Margherita
Ortuño, Cristina Gil
Lacunza, Javier
Giachino, Daniela F.
Cerrato, Natascia
Martins, Raphaël P.
Campuzano, Oscar
Van Dooren, Sonia
Thollet, Aurélie
Kyndt, Florence
Mazzanti, Andrea
Clémenty, Nicolas
Bisson, Arnaud
Corveleyn, Anniek
Stallmeyer, Birgit
Dittmann, Sven
Saenen, Johan
Noël, Antoine
Honarbakhsh, Shohreh
Rudic, Boris
Marzak, Halim
Rowe, Matthew K.
Federspiel, Claire
Le Page, Sophie
Placide, Leslie
Milhem, Antoine
Barajas-Martinez, Hector
Beckmann, Britt-Maria
Krapels, Ingrid P.
Steinfurt, Johannes
Winkel, Bo Gregers
Jabbari, Reza
Shoemaker, Moore B.
Boukens, Bas J.
Škorić-Milosavljević, Doris
Bikker, Hennie
Manevy, Federico C.
Lichtner, Peter
Ribasés, Marta
Meitinger, Thomas
Müller-Nurasyid, Martina
Veldink, Jan H.
van den Berg, Leonard H.
Van Damme, Philip
Cusi, Daniele
Lanzani, Chiara
Rigade, Sidwell
Charpentier, Eric
Baron, Estelle
Bonnaud, Stéphanie
Lecointe, Simon
Donnart, Audrey
Le Marec, Hervé
Chatel, Stéphanie
Karakachoff, Matilde
Bézieau, Stéphane
London, Barry
Tfelt-Hansen, Jacob
Roden, Dan
Odening, Katja E.
Cerrone, Marina
Chinitz, Larry A.
Volders, Paul G.
van de Berg, Maarten P.
Laurent, Gabriel
Faivre, Laurence
Antzelevitch, Charles
Kääb, Stefan
Al Arnaout, Alain
Dupuis, Jean-Marc
Pasquie, Jean-Luc
Billon, Olivier
Roberts, Jason D.
Jesel, Laurence
Borggrefe, Martin
Lambiase, Pier D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9376964
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9376964
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-021-01007-6
