Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the...
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut
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Publisher
New York: Elsevier Inc
Journal title
Language
English
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Publisher
New York: Elsevier Inc
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Scope and Contents
Contents
The chemokine receptor CCR9 equips T cells with the ability to respond to CCL25, a chemokine that is highly expressed in the thymus and the small intestine (SI). Notably, CCR9 is mostly expressed on CD8 but not on CD4 lineage T cells, thus imposing distinct tissue tropism on CD4 and CD8 T cells. The molecular basis and the consequences for such a d...
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Full title
Chemokine receptor CCR9 suppresses the differentiation of CD4+CD8αα+ intraepithelial T cells in the gut
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9391308
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9391308
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ISSN
1933-0219,1935-3456
E-ISSN
1935-3456
DOI
10.1038/s41385-022-00540-9
