PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
The NLRP3 inflammasome, which has been linked to human inflammatory diseases, is activated by diverse stimuli. How these stimuli activate NLRP3 is unknown. Here we show that different NLRP3 stimuli lead to disassembly of the
trans
-Golgi network (TGN). NLRP3 is recruited to the dispersed TGN (dTGN) through ionic bonding between its conserved...
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Full title
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9402428
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9402428
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0761-3
