Cryo-EM structure of an active bacterial TIR–STING filament complex
Cryo-EM structure of an active bacterial TIR–STING filament complex
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Stimulator of interferon genes (STING) is an antiviral signalling protein that is broadly conserved in both innate immunity in animals and phage defence in prokaryotes
1
–
4
. Activation of STING requires its assembly into an oligomeric filament structure through binding of a cyclic dinucleotide
4
–
13
, but the molecular ba...
Alternative Titles
Full title
Cryo-EM structure of an active bacterial TIR–STING filament complex
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9402430
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9402430
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04999-1
