Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
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Author / Creator
Choi, Minee L. , Chappard, Alexandre , Singh, Bhanu P. , Maclachlan, Catherine , Rodrigues, Margarida , Fedotova, Evgeniya I. , Berezhnov, Alexey V. , De, Suman , Peddie, Christopher J. , Athauda, Dilan , Virdi, Gurvir S. , Zhang, Weijia , Evans, James R. , Wernick, Anna I. , Zanjani, Zeinab Shadman , Angelova, Plamena R. , Esteras, Noemi , Vinokurov, Andrey Y. , Morris, Katie , Jeacock, Kiani , Tosatto, Laura , Little, Daniel , Gissen, Paul , Clarke, David J. , Kunath, Tilo , Collinson, Lucy , Klenerman, David , Abramov, Andrey Y. , Horrocks, Mathew H. and Gandhi, Sonia
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Aggregation of alpha-synuclein (α-Syn) drives Parkinson’s disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. In this study, we tracked the intracellular conformational states of α-Syn using a single-molecule Förster resonance energy transfer (smFRET) biosensor, and we...
Alternative Titles
Full title
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Authors, Artists and Contributors
Author / Creator
Chappard, Alexandre
Singh, Bhanu P.
Maclachlan, Catherine
Rodrigues, Margarida
Fedotova, Evgeniya I.
Berezhnov, Alexey V.
De, Suman
Peddie, Christopher J.
Athauda, Dilan
Virdi, Gurvir S.
Zhang, Weijia
Evans, James R.
Wernick, Anna I.
Zanjani, Zeinab Shadman
Angelova, Plamena R.
Esteras, Noemi
Vinokurov, Andrey Y.
Morris, Katie
Jeacock, Kiani
Tosatto, Laura
Little, Daniel
Gissen, Paul
Clarke, David J.
Kunath, Tilo
Collinson, Lucy
Klenerman, David
Abramov, Andrey Y.
Horrocks, Mathew H.
Gandhi, Sonia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9448679
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9448679
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-022-01140-3
