Structural basis for SHOC2 modulation of RAS signalling
Structural basis for SHOC2 modulation of RAS signalling
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The RAS–RAF pathway is one of the most commonly dysregulated in human cancers
1
–
3
. Despite decades of study, understanding of the molecular mechanisms underlying dimerization and activation
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of the kinase RAF remains limited. Recent structures of inactive RAF monomer
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and active RAF dimer
5
–
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bound to 14-3...
Alternative Titles
Full title
Structural basis for SHOC2 modulation of RAS signalling
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9452301
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9452301
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04838-3
