Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression
About this item
Full title
Author / Creator
Ponzo, Matteo , Debesset, Anais , Cossutta, Mélissande , Chalabi-Dchar, Mounira , Houppe, Claire , Pilon, Caroline , Nicolas-Boluda, Alba , Meunier, Sylvain , Raineri, Fabio , Thiolat, Allan , Nicolle, Rémy , Maione, Federica , Brundu, Serena , Cojocaru, Carina Florina , Bouvet, Philippe , Bousquet, Corinne , Gazeau, Florence , Tournigand, Christophe , Courty, José , Giraudo, Enrico , Cohen, José L and Cascone, Ilaria
Publisher
Switzerland: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Switzerland: MDPI AG
Subjects
More information
Scope and Contents
Contents
Background: The pancreatic ductal adenocarcinoma (PDAC) microenvironment is highly fibrotic and hypoxic, with poor immune cell infiltration. Recently, we showed that nucleolin (NCL) inhibition normalizes tumour vessels and impairs PDAC growth. Methods: Immunocompetent mouse models of PDAC were treated by the pseudopeptide N6L, which selectively inh...
Alternative Titles
Full title
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression
Authors, Artists and Contributors
Author / Creator
Debesset, Anais
Cossutta, Mélissande
Chalabi-Dchar, Mounira
Houppe, Claire
Pilon, Caroline
Nicolas-Boluda, Alba
Meunier, Sylvain
Raineri, Fabio
Thiolat, Allan
Nicolle, Rémy
Maione, Federica
Brundu, Serena
Cojocaru, Carina Florina
Bouvet, Philippe
Bousquet, Corinne
Gazeau, Florence
Tournigand, Christophe
Courty, José
Giraudo, Enrico
Cohen, José L
Cascone, Ilaria
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9454580
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9454580
Other Identifiers
ISSN
2072-6694
E-ISSN
2072-6694
DOI
10.3390/cancers14174265
