Potential circadian effects on translational failure for neuroprotection
Potential circadian effects on translational failure for neuroprotection
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Neuroprotectant strategies that have worked in rodent models of stroke have failed to provide protection in clinical trials. Here we show that the opposite circadian cycles in nocturnal rodents versus diurnal humans
1
,
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may contribute to this failure in translation. We tested three independent neuroprotective approaches—normobaric hyp...
Alternative Titles
Full title
Potential circadian effects on translational failure for neuroprotection
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9466001
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9466001
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2348-z
