Spatially restricted drivers and transitional cell populations cooperate with the microenvironment i...
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
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Author / Creator
Cui Zhou, Daniel , Jayasinghe, Reyka G. , Chen, Siqi , Herndon, John M. , Iglesia, Michael D. , Navale, Pooja , Wendl, Michael C. , Caravan, Wagma , Sato, Kazuhito , Storrs, Erik , Mo, Chia-Kuei , Liu, Jingxian , Southard-Smith, Austin N. , Wu, Yige , Naser Al Deen, Nataly , Baer, John M. , Fulton, Robert S. , Wyczalkowski, Matthew A. , Liu, Ruiyang , Fronick, Catrina C. , Fulton, Lucinda A. , Shinkle, Andrew , Thammavong, Lisa , Zhu, Houxiang , Sun, Hua , Wang, Liang-Bo , Li, Yize , Zuo, Chong , McMichael, Joshua F. , Davies, Sherri R. , Appelbaum, Elizabeth L. , Robbins, Keenan J. , Chasnoff, Sara E. , Yang, Xiaolu , Reeb, Ashley N. , Oh, Clara , Serasanambati, Mamatha , Lal, Preet , Varghese, Rajees , Mashl, Jay R. , Ponce, Jennifer , Terekhanova, Nadezhda V. , Yao, Lijun , Wang, Fang , Chen, Lijun , Schnaubelt, Michael , Lu, Rita Jui-Hsien , Schwarz, Julie K. , Puram, Sidharth V. , Kim, Albert H. , Song, Sheng-Kwei , Shoghi, Kooresh I. , Lau, Ken S. , Ju, Tao , Chen, Ken , Chatterjee, Deyali , Hawkins, William G. , Zhang, Hui , Achilefu, Samuel , Chheda, Milan G. , Oh, Stephen T. , Gillanders, William E. , Chen, Feng , DeNardo, David G. , Fields, Ryan C. and Ding, Li
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA sequencing, bulk-proteogenomics, spatial transcriptomics and cellular imaging. Subpopulations of tumor cells exhibited signatures of p...
Alternative Titles
Full title
Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Authors, Artists and Contributors
Author / Creator
Jayasinghe, Reyka G.
Chen, Siqi
Herndon, John M.
Iglesia, Michael D.
Navale, Pooja
Wendl, Michael C.
Caravan, Wagma
Sato, Kazuhito
Storrs, Erik
Mo, Chia-Kuei
Liu, Jingxian
Southard-Smith, Austin N.
Wu, Yige
Naser Al Deen, Nataly
Baer, John M.
Fulton, Robert S.
Wyczalkowski, Matthew A.
Liu, Ruiyang
Fronick, Catrina C.
Fulton, Lucinda A.
Shinkle, Andrew
Thammavong, Lisa
Zhu, Houxiang
Sun, Hua
Wang, Liang-Bo
Li, Yize
Zuo, Chong
McMichael, Joshua F.
Davies, Sherri R.
Appelbaum, Elizabeth L.
Robbins, Keenan J.
Chasnoff, Sara E.
Yang, Xiaolu
Reeb, Ashley N.
Oh, Clara
Serasanambati, Mamatha
Lal, Preet
Varghese, Rajees
Mashl, Jay R.
Ponce, Jennifer
Terekhanova, Nadezhda V.
Yao, Lijun
Wang, Fang
Chen, Lijun
Schnaubelt, Michael
Lu, Rita Jui-Hsien
Schwarz, Julie K.
Puram, Sidharth V.
Kim, Albert H.
Song, Sheng-Kwei
Shoghi, Kooresh I.
Lau, Ken S.
Ju, Tao
Chen, Ken
Chatterjee, Deyali
Hawkins, William G.
Zhang, Hui
Achilefu, Samuel
Chheda, Milan G.
Oh, Stephen T.
Gillanders, William E.
Chen, Feng
DeNardo, David G.
Fields, Ryan C.
Ding, Li
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9470535
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9470535
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-022-01157-1
