Discovery and validation of a transcriptional signature identifying homologous recombination-deficie...
Discovery and validation of a transcriptional signature identifying homologous recombination-deficient breast, endometrial and ovarian cancers
About this item
Full title
Author / Creator
Beinse, Guillaume , Just, Pierre-Alexandre , Le Frere Belda, Marie-Aude , Laurent-Puig, Pierre , Jacques, Sebastien , Koual, Meriem , Garinet, Simon , Leroy, Karen , Delanoy, Nicolas , Blons, Helene , Gervais, Claire , Durdux, Catherine , Chapron, Charles , Goldwasser, François , Terris, Benoit , Badoual, Cecile , Taly, Valerie , Bats, Anne-Sophie , Borghese, Bruno and Alexandre, Jérôme
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
Molecular alterations leading to homologous recombination deficiency (HRD) are heterogeneous. We aimed to identify a transcriptional profile shared by endometrial (UCEC), breast (BRCA) and ovarian (OV) cancers with HRD.
Methods
Genes differentially expressed with HRD genomic score (continuous gHRD score) in UCEC/BRCA/OV were ide...
Alternative Titles
Full title
Discovery and validation of a transcriptional signature identifying homologous recombination-deficient breast, endometrial and ovarian cancers
Authors, Artists and Contributors
Author / Creator
Just, Pierre-Alexandre
Le Frere Belda, Marie-Aude
Laurent-Puig, Pierre
Jacques, Sebastien
Koual, Meriem
Garinet, Simon
Leroy, Karen
Delanoy, Nicolas
Blons, Helene
Gervais, Claire
Durdux, Catherine
Chapron, Charles
Goldwasser, François
Terris, Benoit
Badoual, Cecile
Taly, Valerie
Bats, Anne-Sophie
Borghese, Bruno
Alexandre, Jérôme
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9470569
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9470569
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-022-01900-9
