Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer
Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer
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Publisher
American Society for Clinical Investigation
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Language
English
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American Society for Clinical Investigation
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Contents
Germline loss-of-function mutations of the VHL tumor suppressor gene cause von Hippel-Lindau disease, which is associated with an increased risk of hemangioblastomas, clear cell renal cell carcinomas (ccRCCs), and paragangliomas. This Review describes mechanisms involving the VHL gene product in oxygen sensing, protein degradation, and tumor develo...
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Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9479583
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9479583
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI162480
