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PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9534752

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Expansion and differentiation of antigen-experienced PD-1
+
TCF-1
+
stem-like CD8
+
T cells into effector cells is critical for the success of immunotherapies based on PD-1 blockade
1

4
. Hashimoto et al. have shown that, in chronic infections, administration of the cytokine interleukin (IL)-2 triggers an alternative...

Alternative Titles

Full title

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9534752

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9534752

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-022-05192-0

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