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Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier

Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9547928

Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier

About this item

Full title

Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Acta neuropathologica, 2022-11, Vol.144 (5), p.967-985

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Despite being a major health concern, little is known about the pathophysiological changes that underly concussion. Nonetheless, emerging evidence suggests that selective damage to white matter axons, or diffuse axonal injury (DAI), disrupts brain network connectivity and function. While voltage-gated sodium channels (NaChs) and their anchoring pro...

Alternative Titles

Full title

Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9547928

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9547928

Other Identifiers

ISSN

0001-6322

E-ISSN

1432-0533

DOI

10.1007/s00401-022-02498-1

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