Maturation and circuit integration of transplanted human cortical organoids
Maturation and circuit integration of transplanted human cortical organoids
About this item
Full title
Author / Creator
Revah, Omer , Gore, Felicity , Kelley, Kevin W. , Andersen, Jimena , Sakai, Noriaki , Chen, Xiaoyu , Li, Min-Yin , Birey, Fikri , Yang, Xiao , Saw, Nay L. , Baker, Samuel W. , Amin, Neal D. , Kulkarni, Shravanti , Mudipalli, Rachana , Cui, Bianxiao , Nishino, Seiji , Grant, Gerald A. , Knowles, Juliet K. , Shamloo, Mehrdad , Huguenard, John R. , Deisseroth, Karl and Pașca, Sergiu P.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease
1
–
5
. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other circuits that control behaviour impossible. Here we show that human stem cell-derived co...
Alternative Titles
Full title
Maturation and circuit integration of transplanted human cortical organoids
Authors, Artists and Contributors
Author / Creator
Gore, Felicity
Kelley, Kevin W.
Andersen, Jimena
Sakai, Noriaki
Chen, Xiaoyu
Li, Min-Yin
Birey, Fikri
Yang, Xiao
Saw, Nay L.
Baker, Samuel W.
Amin, Neal D.
Kulkarni, Shravanti
Mudipalli, Rachana
Cui, Bianxiao
Nishino, Seiji
Grant, Gerald A.
Knowles, Juliet K.
Shamloo, Mehrdad
Huguenard, John R.
Deisseroth, Karl
Pașca, Sergiu P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9556304
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9556304
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-05277-w
