Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations
Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mutations in presenilin 1 and 2 (
PS1
and
PS2
) cause autosomal dominant familial Alzheimer’s disease (FAD). Ferroptosis has been implicated as a mechanism of neurodegeneration in AD since neocortical iron burden predicts Alzheimer’s disease (AD) progression. We found that loss of the presenilins dramatically sensitizes multiple cell ty...
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Full title
Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9613996
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9613996
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-022-01003-1
