Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvi...
Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia
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Author / Creator
Rutella, Sergio , Vadakekolathu, Jayakumar , Mazziotta, Francesco , Reeder, Stephen , Yau, Tung-On , Mukhopadhyay, Rupkatha , Dickins, Benjamin , Altmann, Heidi , Kramer, Michael , Knaus, Hanna A. , Blazar, Bruce R. , Radojcic, Vedran , Zeidner, Joshua F. , Arruda, Andrea , Wang, Bofei , Abbas, Hussein A. , Minden, Mark D. , Tasian, Sarah K. , Bornhäuser, Martin , Gojo, Ivana and Luznik, Leo
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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Contents
BackgroundImmune exhaustion and senescence are dominant dysfunctional states of effector T cells and major hurdles for the success of cancer immunotherapy. In the current study, we characterized how acute myeloid leukemia (AML) promotes the generation of senescent-like CD8+ T cells and whether they have prognostic relevance.METHODSWe analyzed NanoS...
Alternative Titles
Full title
Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia
Authors, Artists and Contributors
Author / Creator
Vadakekolathu, Jayakumar
Mazziotta, Francesco
Reeder, Stephen
Yau, Tung-On
Mukhopadhyay, Rupkatha
Dickins, Benjamin
Altmann, Heidi
Kramer, Michael
Knaus, Hanna A.
Blazar, Bruce R.
Radojcic, Vedran
Zeidner, Joshua F.
Arruda, Andrea
Wang, Bofei
Abbas, Hussein A.
Minden, Mark D.
Tasian, Sarah K.
Bornhäuser, Martin
Gojo, Ivana
Luznik, Leo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9621145
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9621145
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI159579
