The adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits
The adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits
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United States: American Society for Cell Biology
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Language
English
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Publisher
United States: American Society for Cell Biology
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Contents
We show that the chaperone AAGAB binds the adaptor protein 4 (AP-4) ε and σ4 subunits, stabilizing them for assembly of the AP-4 complex. In the absence of AAGAB, AP-4 subunits are degraded by the proteasome, levels of the AP-4 complex are reduced, and the AP-4-cargo protein ATG9A accumulates at the TGN, all phenotypes resembling AP-4 deficiency.
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Full title
The adaptor protein chaperone AAGAB stabilizes AP-4 complex subunits
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9635299
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9635299
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ISSN
1059-1524,1939-4586
E-ISSN
1939-4586
DOI
10.1091/mbc.E22-05-0177
