Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kin...
Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status
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Publisher
New York: Springer US
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Language
English
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Publisher
New York: Springer US
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Contents
Deoxycytidine kinase (dCK) and 5’ deoxynucleotidase (NT5C2) are involved in metabolism of cladribine (2CdA), the immunomodulatory drug for multiple sclerosis; by mediating phosphorylation (activation) or phosphorolysis (deactivation) of 2CdA, respectively, these enzymes promote or prevent its accumulation in the cell, which leads to cell death. In...
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Full title
Different Susceptibility of T and B Cells to Cladribine Depends On Their Levels of Deoxycytidine Kinase Activity Linked to Activation Status
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9726780
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9726780
Other Identifiers
ISSN
1557-1890,1557-1904
E-ISSN
1557-1904
DOI
10.1007/s11481-021-09994-3
