High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hi...
High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce metabolic disorder and depressive phenotypes in mice. Initially, we identified an enhanced glutamatergic input in the nucleus accumbens of HFD mice. Retrograde tr...
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High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9734059
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9734059
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-022-01787-1
