Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expressi...
Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Silencing of the
Apoptosis associated Tyrosine Kinase
gene (
AATK
) has been described in cancer. In our study, we specifically investigated the epigenetic inactivation of
AATK
in pancreatic adenocarcinoma, lower grade glioma, lung, breast, head, and neck cancer. The resulting loss of
AATK
correlates with impaired patient su...
Alternative Titles
Full title
Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9750878
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9750878
Other Identifiers
ISSN
0929-1903
E-ISSN
1476-5500
DOI
10.1038/s41417-022-00513-x
