Non-viral precision T cell receptor replacement for personalized cell therapy
Non-viral precision T cell receptor replacement for personalized cell therapy
About this item
Full title
Author / Creator
Foy, Susan P. , Jacoby, Kyle , Bota, Daniela A. , Hunter, Theresa , Pan, Zheng , Stawiski, Eric , Ma, Yan , Lu, William , Peng, Songming , Wang, Clifford L. , Yuen, Benjamin , Dalmas, Olivier , Heeringa, Katharine , Sennino, Barbara , Conroy, Andy , Bethune, Michael T. , Mende, Ines , White, William , Kukreja, Monica , Gunturu, Swetha , Humphrey, Emily , Hussaini, Adeel , An, Duo , Litterman, Adam J. , Quach, Boi Bryant , Ng, Alphonsus H. C. , Lu, Yue , Smith, Chad , Campbell, Katie M. , Anaya, Daniel , Skrdlant, Lindsey , Huang, Eva Yi-Hsuan , Mendoza, Ventura , Mathur, Jyoti , Dengler, Luke , Purandare, Bhamini , Moot, Robert , Yi, Michael C. , Funke, Roel , Sibley, Alison , Stallings-Schmitt, Todd , Oh, David Y. , Chmielowski, Bartosz , Abedi, Mehrdad , Yuan, Yuan , Sosman, Jeffrey A. , Lee, Sylvia M. , Schoenfeld, Adam J. , Baltimore, David , Heath, James R. , Franzusoff, Alex , Ribas, Antoni , Rao, Arati V. and Mandl, Stefanie J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
T cell receptors (TCRs) enable T cells to specifically recognize mutations in cancer cells
1
–
3
. Here we developed a clinical-grade approach based on CRISPR–Cas9 non-viral precision genome-editing to simultaneously knockout the two endogenous TCR genes
TRAC
(which encodes TCRα) and
TRBC
(which encodes TCRβ). We also insert...
Alternative Titles
Full title
Non-viral precision T cell receptor replacement for personalized cell therapy
Authors, Artists and Contributors
Author / Creator
Jacoby, Kyle
Bota, Daniela A.
Hunter, Theresa
Pan, Zheng
Stawiski, Eric
Ma, Yan
Lu, William
Peng, Songming
Wang, Clifford L.
Yuen, Benjamin
Dalmas, Olivier
Heeringa, Katharine
Sennino, Barbara
Conroy, Andy
Bethune, Michael T.
Mende, Ines
White, William
Kukreja, Monica
Gunturu, Swetha
Humphrey, Emily
Hussaini, Adeel
An, Duo
Litterman, Adam J.
Quach, Boi Bryant
Ng, Alphonsus H. C.
Lu, Yue
Smith, Chad
Campbell, Katie M.
Anaya, Daniel
Skrdlant, Lindsey
Huang, Eva Yi-Hsuan
Mendoza, Ventura
Mathur, Jyoti
Dengler, Luke
Purandare, Bhamini
Moot, Robert
Yi, Michael C.
Funke, Roel
Sibley, Alison
Stallings-Schmitt, Todd
Oh, David Y.
Chmielowski, Bartosz
Abedi, Mehrdad
Yuan, Yuan
Sosman, Jeffrey A.
Lee, Sylvia M.
Schoenfeld, Adam J.
Baltimore, David
Heath, James R.
Franzusoff, Alex
Ribas, Antoni
Rao, Arati V.
Mandl, Stefanie J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9768791
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9768791
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-05531-1
