Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Po...
Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases
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Author / Creator
Zhan, Na , Wang, Boyang , Martens, Nikita , Liu, Yankai , Zhao, Shangge , Voortman, Gardi , van Rooij, Jeroen , Leijten, Frank , Vanmierlo, Tim , Kuipers, Folkert , Jonker, Johan W. , Bloks, Vincent W. , Lütjohann, Dieter , Palumbo, Marcella , Zimetti, Francesca , Adorni, Maria Pia , Liu, Hongbing and Mulder, Monique T.
Publisher
Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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Contents
The nuclear receptors—liver X receptors (LXR α and β) are potential therapeutic targets in cardiovascular and neurodegenerative diseases because of their key role in the regulation of lipid homeostasis and inflammatory processes. Specific oxy(phyto)sterols differentially modulate the transcriptional activity of LXRs providing opportunities to devel...
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Full title
Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9863018
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9863018
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms24021290
