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Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progress...

Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progress...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9899627

Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progression

About this item

Full title

Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progression

Publisher

England: John Wiley & Sons, Inc

Journal title

Cancer science, 2023-02, Vol.114 (2), p.348-356

Language

English

Formats

Publication information

Publisher

England: John Wiley & Sons, Inc

More information

Scope and Contents

Contents

Strategies to develop cancer therapies using inhibitors that target matrix metalloproteinases (MMPs), particularly membrane type‐1 MMP (MT1‐MMP), have failed. This is predominantly attributed to the specificity of MMP inhibitors and numerous functions of MMPs; therefore, targeting substrates with such broad specificity can lead to off‐target effect...

Alternative Titles

Full title

Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9899627

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9899627

Other Identifiers

ISSN

1347-9032

E-ISSN

1349-7006

DOI

10.1111/cas.15638

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