Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial
About this item
Full title
Author / Creator
Tian, Jun , Chen, Jonathan H. , Chao, Sherry X. , Pelka, Karin , Giannakis, Marios , Hess, Julian , Burke, Kelly , Jorgji, Vjola , Sindurakar, Princy , Braverman, Jonathan , Mehta, Arnav , Oka, Tomonori , Huang, Mei , Lieb, David , Spurrell, Maxwell , Allen, Jill N. , Abrams, Thomas A. , Clark, Jeffrey W. , Enzinger, Andrea C. , Enzinger, Peter C. , Klempner, Samuel J. , McCleary, Nadine J. , Meyerhardt, Jeffrey A. , Ryan, David P. , Yurgelun, Matthew B. , Kanter, Katie , Van Seventer, Emily E. , Baiev, Islam , Chi, Gary , Jarnagin, Joy , Bradford, William B. , Wong, Edmond , Michel, Alexa G. , Fetter, Isobel J. , Siravegna, Giulia , Gemma, Angelo J. , Sharpe, Arlene , Demehri, Shadmehr , Leary, Rebecca , Campbell, Catarina D. , Yilmaz, Omer , Getz, Gad A. , Parikh, Aparna R. , Hacohen, Nir and Corcoran, Ryan B.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in BRAF
V600E
colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that BRAF/MAPK pathway inhibition may augment the tumor immune response. We performed a proof-of-concept single-arm phase 2 clinical tr...
Alternative Titles
Full title
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial
Authors, Artists and Contributors
Author / Creator
Chen, Jonathan H.
Chao, Sherry X.
Pelka, Karin
Giannakis, Marios
Hess, Julian
Burke, Kelly
Jorgji, Vjola
Sindurakar, Princy
Braverman, Jonathan
Mehta, Arnav
Oka, Tomonori
Huang, Mei
Lieb, David
Spurrell, Maxwell
Allen, Jill N.
Abrams, Thomas A.
Clark, Jeffrey W.
Enzinger, Andrea C.
Enzinger, Peter C.
Klempner, Samuel J.
McCleary, Nadine J.
Meyerhardt, Jeffrey A.
Ryan, David P.
Yurgelun, Matthew B.
Kanter, Katie
Van Seventer, Emily E.
Baiev, Islam
Chi, Gary
Jarnagin, Joy
Bradford, William B.
Wong, Edmond
Michel, Alexa G.
Fetter, Isobel J.
Siravegna, Giulia
Gemma, Angelo J.
Sharpe, Arlene
Demehri, Shadmehr
Leary, Rebecca
Campbell, Catarina D.
Yilmaz, Omer
Getz, Gad A.
Parikh, Aparna R.
Hacohen, Nir
Corcoran, Ryan B.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9941044
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9941044
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-022-02181-8
