Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated mic...
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
The TREM2–DAP12 receptor complex sustains microglia functions. Heterozygous hypofunctional TREM2 variants impair microglia, accelerating late-onset Alzheimer’s disease. Homozygous inactivating variants of
TREM2
or
TYROBP-
encoding DAP12 cause Nasu–Hakola disease (NHD), an early-onset dementia characterized by cerebral atrophy, myelin lo...
Alternative Titles
Full title
Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9992145
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9992145
Other Identifiers
ISSN
1529-2908,1529-2916
E-ISSN
1529-2916
DOI
10.1038/s41590-022-01403-y
