Structural basis of negative feedback regulation in mevalonate kinase inhibition
Structural basis of negative feedback regulation in mevalonate kinase inhibition
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Scope and Contents
Contents
Mevalonate kinase (MK) catalyzes the first of three consecutive ATP-requiring steps in the mevalonate pathway, an essential pathway that diverts acetyl-CoA from primary metabolism to form IPP and DMAPP, the universal five-carbon (C5) precursors to all steroids and isoprenoid natural products in biology. As MK lies at a critical point in the mevalon...
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Full title
Structural basis of negative feedback regulation in mevalonate kinase inhibition
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Record Identifier
TN_cdi_scitation_primary_10_1063_4_0000478
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_scitation_primary_10_1063_4_0000478
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ISSN
2329-7778
E-ISSN
2329-7778
DOI
10.1063/4.0000478
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