Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion o...
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells
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Full title
Author / Creator
Alizadeh, Javad , Zeki, Amir A. , Mirzaei, Nima , Tewary, Sandipan , Rezaei Moghadam, Adel , Glogowska, Aleksandra , Nagakannan, Pandian , Eftekharpour, Eftekhar , Wiechec, Emilia , Gordon, Joseph W. , Xu, Fred. Y. , Field, Jared T. , Yoneda, Ken Y. , Kenyon, Nicholas J. , Hashemi, Mohammad , Hatch, Grant M. , Hombach-Klonisch, Sabine , Klonisch, Thomas and Ghavami, Saeid
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and farnesylpyrophosphate (FPP) used in the prenylation of proteins. Here we show that the MEV cascade inhibitor simvastatin induced significant cell death in a wide range of human tumor cell...
Alternative Titles
Full title
Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells
Authors, Artists and Contributors
Author / Creator
Zeki, Amir A.
Mirzaei, Nima
Tewary, Sandipan
Rezaei Moghadam, Adel
Glogowska, Aleksandra
Nagakannan, Pandian
Eftekharpour, Eftekhar
Wiechec, Emilia
Gordon, Joseph W.
Xu, Fred. Y.
Field, Jared T.
Yoneda, Ken Y.
Kenyon, Nicholas J.
Hashemi, Mohammad
Hatch, Grant M.
Hombach-Klonisch, Sabine
Klonisch, Thomas
Ghavami, Saeid
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_liu_136580
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_liu_136580
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/srep44841
