53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in
53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair—which requires a 3′ overhang—and classical non-homologous end joining, which can join unresected ends
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,
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. BRCA1-mutant cancers show minimal resection of double-strand breaks, which renders them deficient in homology-directed rep...
Alternative Titles
Full title
53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in
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TN_cdi_swepub_primary_oai_DiVA_org_liu_151559
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_liu_151559
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-018-0324-7
