Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major meta...
Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood
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Kidlington: Elsevier Ireland Ltd
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Language
English
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Kidlington: Elsevier Ireland Ltd
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Abstract Venlafaxine (VEN) is an antidepressant drug mainly metabolized by the cytochrome P450 (CYP) enzyme CYP2D6 to the active metabolite O-desmethylvenlafaxine (ODV). VEN is also metabolized to N-desmetylvenlafaxine (NDV) via CYP3A4. ODV and NDV are further metabolized to N,O-didesmethylvenlafaxine (DDV). VEN is a racemic mixture of the S- and R...
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Full title
Influence of CYP2D6 genotype on the disposition of the enantiomers of venlafaxine and its major metabolites in postmortem femoral blood
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TN_cdi_swepub_primary_oai_DiVA_org_liu_72238
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_liu_72238
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ISSN
0379-0738,1872-6283
E-ISSN
1872-6283
DOI
10.1016/j.forsciint.2011.07.034
