Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse...
Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer
About this item
Full title
Author / Creator
Singel, Kelly L. , Grzankowski, Kassondra S. , Khan, A. N. M. Nazmul H. , Grimm, Melissa J. , D’Auria, Anthony C. , Morrell, Kayla , Eng, Kevin H. , Hylander, Bonnie , Mayor, Paul C. , Emmons, Tiffany R. , Lénárt, Nikolett , Fekete, Rebeka , Környei, Zsuzsanna , Muthukrishnan, Uma , Gilthorpe, Jonathan D. , Urban, Constantin F. , Itagaki, Kiyoshi , Hauser, Carl J. , Leifer, Cynthia , Moysich, Kirsten B. , Odunsi, Kunle , Dénes, Ádám and Segal, Brahm H.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
Advanced cancer causes necrosis and releases damage-associated molecular patterns (DAMPs). Mitochondrial DAMPs activate neutrophils, including generation of neutrophil extracellular traps (NETs), which are injurious, thrombogenic, and implicated in metastasis. We hypothesised that extracellular mitochondrial DNA (mtDNA) in ascites fro...
Alternative Titles
Full title
Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer
Authors, Artists and Contributors
Author / Creator
Grzankowski, Kassondra S.
Khan, A. N. M. Nazmul H.
Grimm, Melissa J.
D’Auria, Anthony C.
Morrell, Kayla
Eng, Kevin H.
Hylander, Bonnie
Mayor, Paul C.
Emmons, Tiffany R.
Lénárt, Nikolett
Fekete, Rebeka
Környei, Zsuzsanna
Muthukrishnan, Uma
Gilthorpe, Jonathan D.
Urban, Constantin F.
Itagaki, Kiyoshi
Hauser, Carl J.
Leifer, Cynthia
Moysich, Kirsten B.
Odunsi, Kunle
Dénes, Ádám
Segal, Brahm H.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_umu_156192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_umu_156192
Other Identifiers
ISSN
0007-0920,1532-1827
E-ISSN
1532-1827
DOI
10.1038/s41416-018-0339-8
