Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug
Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug
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Publisher
Boston: Boston : Springer US
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Language
English
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Boston: Boston : Springer US
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Purpose To investigate the prediction accuracy of in vitro and in vitro/in silico methods for in vivo intestinal precipitation of basic BCS class II drugs in humans. Methods Precipitation rate of a model drug substance, AZD0865 (pKa = 6.1; log KD = 4.2), was investigated in vitro using simulated intestinal media, and calculations of the crystalliza...
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Full title
Predicting Intestinal Precipitation—A Case Example for a Basic BCS Class II Drug
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TN_cdi_swepub_primary_oai_DiVA_org_uu_132389
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_132389
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ISSN
0724-8741,1573-904X
E-ISSN
1573-904X
DOI
10.1007/s11095-010-0213-8
