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Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals hig...

Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals hig...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_15630

Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

About this item

Full title

Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

Publisher

United States: Springer Nature B.V

Journal title

Investigational new drugs, 2007-08, Vol.25 (4), p.297-303

Language

English

Formats

Publication information

Publisher

United States: Springer Nature B.V

More information

Scope and Contents

Contents

SDX-308 and SDX-309 are potent indole-pyran analogues of SDX-101 (R-etodolac) which has anti-tumour activity unrelated to cyclooxygenase-2 inhibition. Their cytotoxic activity was further studied herein using a well-characterized human tumour cell-line panel containing ten cell lines, as well as in 58 primary tumour cell samples from a variety of d...

Alternative Titles

Full title

Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_DiVA_org_uu_15630

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_15630

Other Identifiers

ISSN

0167-6997,1573-0646

E-ISSN

1573-0646

DOI

10.1007/s10637-007-9049-4

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